Publications & Research

Academic papers, policy writing, commentary, and books exploring neuroscience, medicine, healthcare innovation, and society.

Books and book chapters

  1. The Evolving Brain: How to Thrive in a World We Weren't Made For. Headline (Hachette), February 2026.

  2. Goldsmith P. and Semple R. (2004) Cases for the MRCP. Hodder.

  3. Goldsmith P. (1998) Case Histories for the MRCP. Butterworth-Heinemann.

  4. Goldsmith P. and Bittencourt P.R.M. (1995) Epileptogenesis in neurocysticercosis: a review. In: Recent Advances in Tropical Neurology, ed. F.C. Rose, pp. 131–140.

Selected policy papers and articles

  1. Goldsmith P. (2026) Why modern work leaves ancient brains exhausted. City AM, 19 May 2026.

  2. Goldsmith P., Colin-Thomé D. and Boyle D. (2020) Localise, equalise and untick: the future of healthcare post-covid. Radix policy paper.

  3. Goldsmith P. (2020) Park life: why we should let locals design their green surroundings. CapX, 17 January 2020.

  4. Goldsmith P. (2019) Politicians could use a lesson in neuroscience. CapX, 21 October 2019. https://capx.co/politicians-could-use-a-lesson-in-neuroscience

  5. Goldsmith P. (2018) Why don't we just… bring William back home. Big Issue North, 10 December 2018. https://www.bigissuenorth.com/comment/2018/12/dont-just-bring-william-back-home/

  6. Goldsmith P. (2018) We can solve Britain's regional imbalance. Comment Central, 24 October 2018. https://commentcentral.co.uk/we-can-solve-britains-regional-imbalance

  7. Goldsmith P. (2018) The Quadruple Helix: tackling the issues of the left behind. Radix Paper No. 10, October 2018. https://www.drpaulgoldsmith.com/s/Quadruple_Helix_E-Final.pdf

Editorials

  1. Goldsmith P. (2015) Separate anecdote from fact: the factors driving complaints in the NHS. Health Service Journal.

  2. Goldsmith P. (2012) We MUST not call it MUS. Pract Neurol 12(4): 271.

Academic papers

2026

2024

  • Collier D.J., Taylor M., Godec T., Shiel J., James R., Chowdury Y., Ebano P., Monk V., Patel M., Pheby J., Pheby R., Foubister A., David C., Saxena M., Richardson L., Siddle J., Timlin G., Goldsmith P., Deeming N., Poulter N.R., Gabe R., McManus R.J., Caulfield M.J. (2024) Personalized antihypertensive treatment optimization with smartphone-enabled remote precision dosing of amlodipine during the COVID-19 pandemic (PERSONAL-CovidBP Trial). J Am Heart Assoc 13(4): e030749.

  • Sedley W., Kumar S., Jones S., Levy A., Friston K., Griffiths T., Goldsmith P. (2024) Migraine as an allostatic reset triggered by unresolved interoceptive prediction errors. Neurosci Biobehav Rev 157. https://pubmed.ncbi.nlm.nih.gov/38185265/

  • Goldsmith P. and Taylor M. (2024) Revolutionising hypertension management through personalised data driven dose optimisation. Journal of Clinical Studies 15(4): 23–24. https://journalforclinicalstudies.com/revolutionising-hypertension-management-through-personalised-data-driven-dose-optimisation/

2023

  • Goldsmith P. (2023) Asked and answered: interview with Dr Paul Goldsmith. Inside Precision Medicine.

2022

  • Taylor M., Godec T., Shiel J., James R., Chowdury Y., Ebano P., Monk V., Patel M., Pheby J., Enobakhare E., Foubister A., Clovell D., Saxena M., Siddle J., Timlin G., Goldsmith P., Deeming N., Poulter N., Gabe R., McManus R., Collier D. (2022) Whose dose is it anyway? Individual patient dose-response curves from the remote-care Personal CovidBP Trial. American College of Cardiology (abstract).

2020

  • Goldsmith P. (2020) Are these visual symptoms due to migraine? A guide for general practice. Br J Gen Pract 70(691): 88–89.

2018

  • Bolton C. and Goldsmith P. (2018) Complaints from patients with functional neurological disorders: a cross-sectional UK survey of why patients complain and the effect on the clinicians who look after them. BMJ Open 8.

2015

  • Goldsmith P., Moon J., Anderson P., Kirkup S., Williams S., Gray M. (2015) Do clinical incidents, complaints and medicolegal claims overlap? Int J Health Care Qual Assur 28(8): 864–871.

2014

  • Anderson K.N., Goldsmith P., Gardiner A. (2014) A pilot evaluation of an online cognitive behavioral therapy for insomnia disorder: targeted screening and interactive web design lead to improved sleep in a community population. Nat Sci Sleep 6: 43–49.

2013

  • Fleming A., Diekmann H., Goldsmith P. (2013) Functional characterisation of the maturation of the blood-brain barrier in larval zebrafish. PLoS One 8(10): e77548.

2011

  • Lavender T., Goldsmith P., Whittaker R., Schwab U. (2011) Botulism, recreational drug use revisited: inhalational poisoning or wound infection? J Infect 63(6): e117–e118.

2010

  • Buckley C.E., Marguerie A., Roach A.G., Goldsmith P., Fleming A., Alderton W.K., Franklin R.J. (2010) Drug reprofiling using zebrafish identifies novel compounds with potential pro-myelination effects. Neuropharmacology 59(3): 149–159.

  • Fleming A., Jankowski J., Goldsmith P. (2010) In vivo analysis of gut function and disease changes in a zebrafish larvae model of inflammatory bowel disease: a feasibility study. Inflamm Bowel Dis 16(7): 1162–1172.

2009

  • Diekmann H., Anichtchik O., Fleming A., Futter M., Goldsmith P., Roach A., Rubinsztein D.C. (2009) Decreased BDNF levels are a major contributor to the embryonic phenotype of huntingtin knockdown zebrafish. J Neurosci 29(5): 1343–1349.

  • Seipold S., Priller F.C., Goldsmith P., Harris W.A., Baier H., Abdelilah-Seyfried S. (2009) Non-SMC condensin I complex proteins control chromosome segregation and survival of proliferating cells in the zebrafish neural retina. BMC Dev Biol 9: 40.

2008

  • Buckley C.E., Goldsmith P., Franklin R.J. (2008) Zebrafish myelination: a transparent model for remyelination? Dis Model Mech 1(4–5): 221–228.

  • Goldsmith P., Lennox G.G., Kapur N. (2008) Azathioprine prescribing in neurology. J Neurol 255(6): 791–795.

  • Anichtchik O., Diekmann H., Fleming A., Roach A., Goldsmith P., Rubinsztein D.C. (2008) Loss of PINK1 function affects development and results in neurodegeneration in zebrafish. J Neurosci 28(33): 8199–8207.

  • Williams A., Sarkar S., Cuddon P., Ttofi E.K., Saiki S., Siddiqi F.H., Jahreiss L., Fleming A., Pask D., Goldsmith P., O'Kane C.J., Floto R.A., Rubinsztein D.C. (2008) Novel targets for Huntington's disease in an mTOR-independent autophagy pathway. Nat Chem Biol 4(5): 295–305.

  • Berghmans S., Butler P., Goldsmith P., Waldron G., Gardner I., Golder Z., Richards F.M., Kimber G., Roach A., Alderton W., Fleming A. (2008) Zebrafish based assays for the assessment of cardiac, visual and gut function: potential safety screens for early drug discovery. J Pharmacol Toxicol Methods 58(1): 59–68.

  • Best J.D., Berghmans S., Hunt J.J., Clarke S.C., Fleming A., Goldsmith P., Roach A.G. (2008) Non-associative learning in larval zebrafish. Neuropsychopharmacology 33(5): 1206–1215.

  • Goldsmith P., Patel A., Farmer R., Wright G., Brown J. (2008) A novel technique for imaging the brain of the obese patient. Clin Radiol 63: 575–576.

2007

  • Berghmans S., Hunt J., Roach A., Goldsmith P. (2007) Zebrafish offer the potential for a primary screen to identify a wide variety of potential anticonvulsants. Epilepsy Res 75: 18–28.

  • Goldsmith P., Golder Z., Hunt J., Berghmans S., Jones D., Stables J.P., Murphree L., Howden D., Newton P.E., Richards F.M. (2007) GBR 12909 possesses anticonvulsant activity in zebrafish and rodent models of generalized epilepsy but cardiac ion channel effects limit its clinical utility. Pharmacology 79: 250–258.

  • Goldsmith P. and Roach A. (2007) Methods to enhance the safety of methotrexate prescribing. J Clin Pharm Ther 32(4): 327–331.

2005

  • Fleming A., Sato M., Goldsmith P. (2005) High-throughput in vivo screening for bone anabolic compounds with zebrafish. J Biomol Screen 10: 823–831.

2004

  • Goldsmith P. (2004) Zebrafish as a pharmacological tool: the how, why and when. Curr Opin Pharmacol 4: 1–8.

  • Goldsmith P. and Lennox G.G. (2004) How good at neurology are you? Pract Neurol 4: 252–253.

  • Goldsmith P., Lennox G.G. and Ray J. (2004) How good at neurology are you? Pract Neurol 4: 186–193.

  • Goldsmith P. and Lennox G.G. (2004) How good at neurology are you? Pract Neurol 4: 118–119.

  • Goldsmith P. and Lennox G.G. (2004) How good at neurology are you? Pract Neurol 4: 60–64. https://doi.org/10.1111/j.1474-7766.2004.15-179.x

2003

  • Goldsmith P. and Lennox G.G. (2003) How good at neurology are you? Pract Neurol 3: 378–385. https://doi.org/10.1111/j.1474-7766.2003.13-195.x

  • Goldsmith P. and Lennox G.G. (2003) How good at neurology are you? Pract Neurol 3: 322–324.

  • Goldsmith P. and Lennox G.G. (2003) How good at neurology are you? Pract Neurol 3: 251–253. https://doi.org/10.1046/j.1474-7766.2003.12171.x

  • Goldsmith P., Baier H. and Harris W.A. (2003) Two zebrafish mutants, ebony and ivory, uncover benefits of neighborhood on photoreceptor survival. J Neurobiol 57: 235–245.

  • Goldsmith P. and Lennox G.G. (2003) How good at neurology are you? Pract Neurol 3: 186–192. https://doi.org/10.1046/j.1474-7766.2003.13154.x

  • Goldsmith P. and Lennox G.G. (2003) How good at neurology are you? Pract Neurol 3: 122–127. https://doi.org/10.1046/j.1474-7766.2003.15142.x

  • Goldsmith P. and Harris W.A. (2003) The zebrafish as a tool for understanding the biology of visual disorders. Semin Cell Dev Biol 14: 11–18.

  • Goldsmith P., Ong E.L.C. and Shaw P.J. (2003) Encephalopathy following tropical scuba diving. CPD Infection 4: 24–25.

  • Goldsmith P. and Lennox G.G. (2003) How good at neurology are you? Pract Neurol 3: 46–51. https://doi.org/10.1046/j.1474-7766.2003.00122.x

  • Goldsmith P. and Solari R. (2003) The role of zebrafish in drug discovery. Drug Discovery World: 74–78.

2002

2001

  • Goldsmith P. (2001) Modelling eye diseases in the zebrafish. Neuroreport 12: 73–77.

1996

  • Goldsmith P., Sandman M.C., Souza D.S., Mazer S., Antoniuk A., Bittencourt P.R.M. (1996) The relationship between parasite location and electroclinical abnormality in neurocysticercosis. Neurol Infect Epidemiol 1: 127–133.

1995

1994

  • Goldsmith P. (1994) Plant stems: a possible model system for the transduction of mechanical information in bone modeling [Editorial]. Bone 15(3): 249–250. https://doi.org/10.1016/8756-3282(94)90285-2

    Written while I was still a medical student at Oxford. It asks whether the way a plant stem toughens up in the wind might teach us something about how bone responds to load. I didn't have a name for it then, but looking back, it was my first attempt at evolutionary, cross-system thinking.

1993

  • Flament D., Goldsmith P., Buckley C.J. and Lemon R.N. (1993) Task-dependence of EMG responses in first dorsal interosseous muscle to magnetic brain stimulation in man. J Physiol 464: 361–378.

1992

  • Flament D., Goldsmith P. and Lemon R.N. (1992) The development of corticospinal projections to tail and hindlimb motorneurons studied in infant macaques using magnetic brain stimulation. Exp Brain Res 90: 225–228.

  • Goldsmith P., Flament D. and Lemon R.N. (1992) Task-related differences in the responses of human first dorsal interosseous (1DI) muscle to magnetic brain stimulation. J Physiol 446: 226 (abstract).

1991

  • Goldsmith P., Flament D. and Lemon R.N. (1991) Evidence for task related activity in the human motor cortex. Eur J Neurosci Suppl 4: 311 (abstract).

  • Goldsmith P., Flament D. and Lemon R.N. (1991) Human motor cortex control of different levels of voluntary contraction. Eur J Neurosci Suppl 4: 311 (abstract).

Case reports

  1. Miltenberger-Miltenyi G., Bader B., Velayos-Baeza A., Burghaus L., Goldsmith P., Abicht A., Bhidayasiri R., Balakrishnan N., Simon D., Walker R., Lubarr N., Danek A. (2021) Normal chorein signal on red cell membrane Western blotting in VPS13A disease. 10th International Meeting on Neuroacanthocytosis Syndromes (abstract).

  2. Martikainen M.H., Gorman G.S., Goldsmith P., Burn D.J., Turnbull D.M., Schaefer A.M. (2015) Adult-onset myoclonus ataxia associated with the mitochondrial m.8993T>C "NARP" mutation. Mov Disord 30(10): 1432–1433.

  3. Cassidy A.J., Williams E.R., Goldsmith P., Baker S.N., Baker M.R. (2011) The man who could not walk backward: an unusual presentation of neuroferritinopathy. Mov Disord 26(2): 362–364.

  4. Gallagher P., Archibald N., Goldsmith P., Burn D. (2010) Two in the hand, an essential lesson in tremor management. Pract Neurol 10(3): 160–163.

  5. Goldsmith P., Jones R.E., Ozuzu G.E., Richardson J. and Ong E.L. (2000) Optic neuropathy as the presenting feature of HIV infection: recovery of vision with highly active antiretroviral therapy. Br J Ophthalmol 84: 551–553.

  6. Goldsmith P., Burn D.J., Coulthard A. and Jenkins A. (1999) Extrinsic cerebral venous sinus obstruction resulting in intracranial hypertension. Postgrad Med J 75: 550–551.

  7. Goldsmith P., Jaeger R., Rowe D. and Kapoor R. (1998) Focal vertebral artery dissection causing a Brown-Séquard syndrome. J Neurol Neurosurg Psychiatry 64: 415–416.

  8. Goldsmith P., Meikle D. and Soames J. (1995) Leiomyomatous hamartoma of the posterior tongue: a case report. J Laryngol Otol 109: 1190–1191.

  9. Goldsmith P., Meikle D., Zammitt I. and Cameron R. (1995) Intracanalicular neuritis in the Ramsay Hunt syndrome mimicking an acoustic neuroma on MRI. J Laryngol Otol 109: 1013–1015.